The Chemistry of Escitalopram

Introduction

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Escitalopram is used to help treat depression and mild GAD which is generalized anxiety disorder. It will help cure excessive worry and also tension that disrupts daily life. It is in a class of depressions called (SSRIs) which stands for serotonin reuptake inhibitors. It works by increasing the amount of serotonin in the body which is a natural substance that helps maintain the balance.  Escitalopram interested me on how it actually works on the body. I have been taking Escitalopram (Lexapro) for about three months now, and i have been curious on how it is helping to balance my body.


Composition of ...

The components of Escitalopram are mostly there to help disperse one major component which is Escitalopram Oxalate. The components include; talc, croscarmellose sodium, microcrystalline cellulose/colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol.


Main Chemicals, Compounds, Components

  • Escitalprom oxalate

o   The first thought of an antidepressant drug was made by H. Lundbeck A/S and

Forest Laboratories, Inc. in 1997. It became a FDA approved drug in 2003. It was developed by them isolating a part of the molecule citalopram HBr, which is known as an isomer. The escitalopram oxalate occurs as a white powder that is put into round tablets. The strength of the pills are generally equivalent to 5mg, 10mg, and 20mg. It is used for a variety of mental health problems but most commonly used to treat; major depression disorders and/or generalized anxiety disorders. It does this by increasing certain levels of chemicals in the brain like serotonin. The antidepressant action of it is linked to the serotonergic energy in the  Central Nervous System (CNS) which results its inhibitory effect on the reuptake.

  • Hypromellose

oFor the particular pill, it is used as the controlling agent for releasing the medicinal compound into the digestive tract. It delays the reaction so that the pill doesn’t disappear after a hour and slowly releases it through out the following 24 hours. It can also help bind together the tablet coating to the powder inside. When it is heated up to a critical temperature, it turns into a nonflowable product that helps it stay longer in the stomach


Chemistry's Role

Depression is known to be liked to low levels of natually-occuring chemical messengers called neuro-transmitters. There are two different kind of neuro-transmitters which are called serotonin and noradrenaline. Serotonin is thought to be a contributor to feeliings of well-being and happines.  Escitalopram is known as an anitidepressant or anti-anxiety medicine and belongs in the selective serotonin reuptake inhibitors (SSRIs). It works by increasing the levels of serotonin in the brain. It does this by getting into the neuro-transmitters in the brain, making it think that it is happy. This then causes the brain to release more levels of serotonin.


Background Research

Escitalopram is made man made and is put together in labs. It is done presicely by computers so that each pill is exactly right. This pill has been getting researched for almost two decades. It’s chemical equation is C20H21FN2O, and is held together by a synthesis reaction. Its main job is to enhance the amount of serotionin in the brain, which causes the sensation of happiness.


Resources

http://www.frx.com/products/lexapro.aspx  http://www.frx.com/pi/Lexapro_pi.pdf

Drug Interactions and a list of the drugs in the pills

Ever information about effects of this pill


http://www.rxlist.com/lexapro-drug.htm

Drug description and the use of it.


http://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/21-365_Lexapro_Chemr.pdf

Chemistry and the bonds of lexapro


http://www.medicinenet.com/escitalopram/article.htm

Drug interactions, side effects, and dosing


http://www.nlm.nih.gov/medlineplus/druginfo/meds/a603005.html

General information about the drug


http://en.wikipedia.org/wiki/Escitalopram

Everything about it except for chemical reactions


http://www.glutenfreedrugs.com/Excipients.htm

how hypromellase is made


http://whatyoushouldknow.depression-alliance.co.uk/antidepressants/escitalopram/

How it works in the body

About the Author

Aly Rigney is a junior at Billings Senior High School. She enjoys hunting and learning about how the body works. She is currently interested in becoming a physician assistant and would like to go to Rocky Mountain College when she graduates. Aly is looking forward to spending more of her time volunteering for her local hospitals.

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