The Chemistry of Pain
Pain is the distressing feeling one gets when a type of tissue is damaged, and is a symptom of many medical ailments. You might think that life without pain would be much better than the life you currently lead. Well think again. Pain is one of the body’s defense mechanisms and is vital to survival. It triggers a response that is designed to force one to withdraw from the danger, protect the affected area until completely healed, and avoid similar predicaments in the future. In fact, those who are insensitive to pain have shorter life expectancies than those who aren’t. The best assessment of pain does in fact come from the person that is experiencing the pain, and their knowledge of the events that resulted in pain, location of pain, and intensity can be vitally crucial to revealing the actual medical ailment occurring in the body.
I chose to do the Chemistry of Pain due to the fact that pain is and has been present in my life extensively, whether it is me suffering through an injury or ailment or watching others endure their own pain. Throughout my life, pain has had a major effect on it, as it has helped me learn and adapt to different situations and has allowed me to prevent certain situations and conditions from occurring again.
Composition of ...
Substance P= C63H98N18O13S
Neurokinin A= C50H80N14O14S
Main Chemicals, Compounds, Components
Glutamate (C5H8NO4-), which is found in the cell membranes of neurons throughout the nervous system and the most abundant neurotransmitter in the brain, is responsible for many things, such as brain development, memory, learning, and of course nociception (pain processing). This neurotransmitter, when involved with nociception, is found at the synapses along the nerves that consist of the pain processing path. By binding with its protein receptors found only on specific cells, it carries the signal known as pain to the CNS (Central Nervous System) and up to the brain.
Substance P (C63H98N18O13S) is a tachykinin neuropeptide involved with the transmission of pain. As with Glutamate, it is found within the synapses along the nerves that consist of the pain processing path. During nociception, it binds with its receptor, Neurokinin 1 (found on the neurons in the area of the spine known as the dorsal horn) to transmit the signal of pain to the brain. In addition, it can cause the release of substances, such as bradykinin (causes a drop in blood pressure), histamine (induces inflammatory response), and serotonin (starts wound healing).
Both components (substance P and Glutamate) are naturally occurring neurotransmitters that are found throughout the CNS. The final product (pain) is a result of not only the amounts of both of these neurotransmitters, but the overall effects. The whole process of pain acts kind of like a chemical reaction, as several products are created throughout the nociceptive process. When a stimuli acts upon a nociceptive neuron, it sends a message through the nerves. At the synapses of these nerves, neurotransmitters and neuropeptides await, and transmit the signal to their corresponding receptors. Substance P, for example, binds to neurokinin 1 to transmit the signal. During that process, it causes a release of bradykinin, histamine, and serotonin. Bradykinin causes a drop in blood pressure, which is an involuntary response to pain. Histamine causes the inflammatory response, which increases permeability to white blood cells and other proteins to prevent or fight infection. Serotonin is released by platelets involved in a clot, which constricts blood vessels to maintain homeostasis, and is also a growth factor, giving it a role in wound healing. When the signal reaches the thalamus of the brain, it goes to the prefrontal cortex, hypothalamus, and amygdala for further processing. In addition, the brain releases dopamine into the basal ganglia and nucleus accumbens. The basal ganglia helps process the pain itself, while the nucleus accumbens affects the emotional experience. When the brain fully processes the information it has received, it generates a response, often a reflex of some sort to withdraw oneself from the painful situation and helps them learn to avoid it in the future. Finally, the brain releases various chemicals, such as Serotonin, norepinepherine, endorphins, and enkephalins to reduce the pain and start the healing process.
Overall, pain is the distressing feeling one gets when a type of tissue is damaged, and is a symptom of many medical ailments. You might think that life without pain would be much better than the life you currently lead. Well think again. Pain is one of the body’s defense mechanisms and is vital to survival. It triggers a response that is designed to force one to withdraw from the danger, protect the affected area until completely healed, and avoid similar predicaments in the future. In fact, those who are insensitive to pain have shorter life expectancies than those who aren’t. The best assessment of pain does in fact come from the person that is experiencing the pain, and their knowledge of the events that resulted in pain, location of pain, and intensity can be vitally crucial to revealing the actual medical ailment occurring in the body.
Genes also play an important role in how sensitive to pain a person is. Now there are a lot of genes that work in several different combos to determine how sensitive one is, but there are a couple major ones. The TrpV1 gene is responsible for sensitivity towards temperature related pain. In addition, the COMT gene plays an important role in sensitivity. The less active that gene is, the less sensitive one is to pain. Finally, different genes produce the different substances involved in pain. For example, the TAC1 gene is involved in the production of Substance P.
Genes involved with pain sensitivity
Areas of the CNS where pain signals are sent through
Types of nerves involved with pain transmission
Chemicals, neurotransmitters and peptides involved
Types of Nociceptors
What parts of the body produce certain chemicals
Parts of the brain involved
Chemicals involved in pain reduction
General information on Substance P
Substance P’s and glutamates role in pain transmission
Location of neurotransmitters and peptides
Products of Substance P/Neurokinin 1 reaction
Chemicals released that increase sensitivity
Parts of the brain involved with pain processing
Information on glutamate
Location of glutamate
Glutamate and its reactions with its receptors
Dopamine’s role in pain processing
Types of pain
Chemical formulas of dynorphins and dopamine
General information/definition of pain
Chemical formula of norepinephrine
Chemical formula of Neurokinin A
Tachykinin peptides and genes that produce them
Chemical formula of Substance P
Chemical formula of Met-enkephalin
Chemical formula of Serotonin
Potential healing role in Serotonin
Chemical formula of Glutamate
Chemical formula of Leu-enkephalin
General information on Bradykinin
General information on histamine
General information on TAC1 gene
About the Author
Caleb Johnson is a Junior at Billings Senior High School. Aside from being a highly accomplished student, he is heavily involved in the wrestling team based at the school. He looks to expand his knowledge in various sciences, and hopes one day to go to college to learn to be a Physical Therapist or Sports Trainer.